Secure Bioinformatics and Genomics Cloud, Software and Services

Reliable discovery by fast BLAST of custom, standard, and SRA databases, powerful visualization, streamlined collaboration, and intuitive comparative browsing.

SequenceServer empowers researchers with data-driven insights.
It's trusted by researchers in hundreds of organizations and has been cited in ~300 publications.

Built-in genomics & bioinformatics expertise

  • AI-assisted user interface
  • Intuitive visualizations
  • Custom assembly, genotyping, GWAS and more

No servers or UNIX necessary

  • Secure, reliable & accurate
  • BLAST, SRA BLAST, Genome Browsers
  • On-demand scaling

Designed for Collaboration

  • Centralized data store
  • Analysis sharing & annotation
  • History & audit trails
  • Training & education
Overview of different SequenceServer functionalities

Genomics data is key to understanding diseases, designing new drugs, ensure food quality and security, measuring and protecting the environment. We want to also help you to make bold impactful discoveries.

SequenceServer is the best tool for BLASTing standard and custom genomes and transcriptomes. No queues or unreasonable limitations. It's also great for BLASTing SRA, getting gene annotations, infering gene function, browsing genomes, and for sharing and annotating data and results with your team, students, or community.

Organizations worldwide use SequenceServer

Many different organisations use SequenceServer for their research Many different organisations use SequenceServer for their research

And academics cite our 2019 MBE paper almost weekly, with over 290 total (check Google Scholar or a slightly dated list here).

Benefits of using SequenceServer Cloud

Just do the research

Focus on the science, not UNIX, servers, updates or waiting for NCBI.

Simply upload FASTA files or select standard sequence databases. Begin BLASTing within seconds. ~300 citations can't be wrong.
Focus on the biology.

Powerful visualizations

Gain deep insight through diverse visualization approaches.

All BLAST results include pairwise alignment graphs, Circos-style overview plots, and length distribution histograms. These plots clarify and help to interpret analysis results. Publication-ready export in .PNG or .SVG formats. You work faster and more accurately.

Intelligent user interface

Faster & more accurate.

Our user interface elegantly aims to make you happy. "AI" detection of nucleotides vs amino-acids. Automagic FASTQ to FASTA conversion. Automagic selection of the best BLAST method.
Such features accelerate your workflow and reduce your chances of making errors.

Share and collaborate

Have a central SequenceServer database for your team.

Share databases and analyses with colleagues. Foster collaboration and knowledge-sharing within your team. Annotate and comment on BLAST analyses (like in Acrobat). Share result with peers to leverage their expertise.

Export data in various formats

Streamline your R&D by integrating with other tools.

Download BLAST reports as HTML, XML or tab-delimited text. Programmatically submit and retrieve remote BLAST searches using python or command-line API. Import results into R or python. Export FASTA hit sequences or pairwise alignments. Link out to NCBI, Uniprot, jBrowse, IGV, or custom databases.

Custom links and design

Customize your SequenceServer and integrate it with other resources.

Add links from search hits to custom genome browsers or domain-specific databases. Integrate SequenceServer with other parts of your lab or community website. Change fonts, colors, and logos.

Don't melt your laptop!

SequenceServer Cloud supports intense and long-running queries.

SequenceServer Cloud is high-performance, high-availability, and scalable BLAST platform. It won't overheat (unlike your laptop!). Your BLAST search starts instantly. We intelligently leverage cloud computing to support large queries. Keep your laptop for lap-top-work.

Support your students

Intuitive BLAST analysis for large student cohorts.

No more waiting at the NCBI website. We leverage cloud computing to instantly start your BLAST search. SequenceServer intelligently scales to access (almost) infinite cloud resources. Hundreds of students can run BLAST seraches simultaneously. Perfect for teaching labs with large class sizes. Our intuitive user interface and visualizations flatten learning curves. Monitor student engagement with detailed logging.

Robust, Secure and private

Secured to the higest standards.

We prioritize your data's security and privacy. With advanced SSL/TLS encryption, proactive firewalls, intrusion detection, and exclusive Virtual Private Clouds (VPCs), we safeguard your data to the highest industry standards. Control access with popular Single-Sign-On (SSO) providers and track interactions with detailed audit trail logs. Trusted by academics, biotech, pharma, and agro-industry users worldwide, we're committed to protecting your data as if it were our own.

Use Cases

Comparative Genomics

Compare genomes across multiple species, identify conserved regions, protein domains, homologous genes, copy number differences, sequence differences, species, and evolutionary relationships. Deepen our understanding of the genetic basis of various biological traits and functions, and evolutionary histories.

Gene Curation and Annotation

Validate and refine gene predictions using SequenceServer BLAST searches against known gene sequences and protein domains. Identify potential inaccuracies in gene annotations and improve the qualities of genesets and genome assemblies.

Visual Analyses

Make graphs for visualizing and publishing. Get a range of BLAST plots, such as summary statistics, pairwise alignments and hit length distributions. Explore SRA read alignments, SNPs and INDELs with the IGV genome browser. Make and scrutinize gene and protein domain annotations with DNA Visualizer.

Design Diagnostic Markers

SequenceServer helps identify unique sequence regions in viruses, bacteria or other target organisms that can serve as diagnostic markers for disease detection. Design PCR or qPCR primers and probes, or specific guide RNA oligos (gRNA) for CRISPR/Cas9 assays. Improving the specificity and sensitivity of molecular-genomic approaches supports disease surveillance and management efforts.

Functional Characterization

Identify and analyze novel genes of interest in non-model organisms, as well as newly sequenced or understudied genomes. By comparing these sequences to known genes in other organisms, researchers can gain insights into the potential functional domains and biological roles of the newly discovered genes, guiding further experimental validation and functional studies.

Variant Calling Analysis

Explore DNA/RNA sequencing data from the NCBI Short Read Archive. Build SNP marker arrays for agricultural breeding. Identify and distinguish genetic variants in sequence data from wild species. Perform genome-wide mapping. Output alignment results for downstream analyses.

Data Hosting and Genome Browsers

Do you want to share genomes and annotations for your favourite species publicly or privately? SequenceServer makes sharing with others in your team or the wider community easy. Explore your data together with comments and genome browsers. Make your data have more impact.

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SequenceServer is open source

Always Open Source

SequenceServer Cloud has many features that enhance productivity. But we started open source, and are proud to keep our core open source and free for those who want to run their own servers. Explore our documentation, connect with us our community support forum, or submit a PR to the GitHub repository. Together, we're advancing bioinformatics one BLAST at a time.

Ready to Revolutionize Your Sequence Analysis?

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